Douxo S3 Pyo Shampoo, Contains 3% Chlorhexidine & 0.5% Ophytrium, Antiseptic & Hydrating, For Bacterial or Yeast Skin Infections, For Dogs and Cats, 6.7 fl. oz. (200mL)
Original price was: $24.99.$21.99Current price is: $21.99.







Price: $24.99 - $21.99
(as of Oct 27, 2025 04:27:23 UTC – Details)
Soothes, cleans and strengthens the skin barrier. Moisturizes and detangles the fur to leave the coat soft and shiny. DOUXO is the #1 non-prescription topical brand used and recommended by U.S. veterinarians for treatment of dogs and cats with inflammatory dermatological diseases.
Package Dimensions : 5.94 x 2.48 x 1.81 inches; 6.7 ounces
Item model number : D98410M
Date First Available : May 5, 2021
Manufacturer : Douxo S3
ASIN : B0947674MT
Best Sellers Rank: #420 in Pet Supplies (See Top 100 in Pet Supplies) #3 in Dog Shampoos
Customer Reviews: 4.7 4.7 out of 5 stars 6,263 ratings var dpAcrHasRegisteredArcLinkClickAction; P.when(‘A’, ‘ready’).execute(function(A) { if (dpAcrHasRegisteredArcLinkClickAction !== true) { dpAcrHasRegisteredArcLinkClickAction = true; A.declarative( ‘acrLink-click-metrics’, ‘click’, { “allowLinkDefault”: true }, function (event) { if (window.ue) { ue.count(“acrLinkClickCount”, (ue.count(“acrLinkClickCount”) || 0) + 1); } } ); } }); P.when(‘A’, ‘cf’).execute(function(A) { A.declarative(‘acrStarsLink-click-metrics’, ‘click’, { “allowLinkDefault” : true }, function(event){ if(window.ue) { ue.count(“acrStarsLinkWithPopoverClickCount”, (ue.count(“acrStarsLinkWithPopoverClickCount”) || 0) + 1); } }); });
#1 non-prescription topical brand used and recommended by U.S. veterinarians for dogs and cats with infections/inflammatory dermatological disease
Proven to disinfect, hydrate and help support the skin’s ecosystem and reduce yeast counts in 7 days
Contains ophytrium, a purified natural ingredient that helps support the skin’s physical barrier for supple hydrated skin and helps soothe irritated skin
Free from soaps, sulfates, parabens, dyes and nanoparticles
For best results use with the DOUXO PYO Mousse
Customers say
Customers find this medicated shampoo effective, particularly for bacterial and yeast skin infections, with one noting it eliminated problems in three weeks. The product receives positive feedback for its ability to stop itching and clear up cats’ itchy skin, while leaving fur soft and shiny. They appreciate its pleasant smell and its effectiveness in treating skin conditions, with one customer noting their dog’s coat and skin became glossy. While some customers consider the price worth it, others find it too expensive for the small bottle size.
12 reviews for Douxo S3 Pyo Shampoo, Contains 3% Chlorhexidine & 0.5% Ophytrium, Antiseptic & Hydrating, For Bacterial or Yeast Skin Infections, For Dogs and Cats, 6.7 fl. oz. (200mL)
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Original price was: $24.99.$21.99Current price is: $21.99.
Sharon M –
Worth EVERY Penny
This shampoo has been an absolute game-changer for my dog. Sheâs 13 years old now and has struggled with itching her entire life. Weâve tried just about everything over the yearsâmultiple prescriptions, countless vet-recommended products, and so many over-the-counter solutions. Nothing ever gave her real relief until we started using this shampoo along with the mousse.The difference has been incredible. She used to spend her days constantly scratching and licking, and nights were often the worstâwaking up itching, sometimes even crying out in discomfort. It was heartbreaking to watch. Since switching to this product sheâs finally comfortable. She sleeps peacefully through the night now, complete with the sweetest little snores, and during the day sheâs relaxed instead of restless. Itâs been amazing to see her quality of life improve so dramatically.Iâve been using this consistently for months and Iâm a repeat purchaserâIâll never be without it. It not only calms her skin but also keeps her coat soft, clean, and so fresh smelling. I did find that buying directly from the company offers a better price, but regardless, this shampoo (and mousse) are worth every penny.If you have a dog struggling with chronic itching or irritated skin, I canât recommend this product enough. It has truly been the only thing that has worked for us after years of searching, and itâs given my dog the comfort she deserves.
Heather –
5 Stars – HIGHLY Recommend! Works Amazing for Allergies!
Hands down the best dog shampoo I’ve ever used.y American Pitbull is allergic to everything,I even had him undergo the prick test with the Dermatologist & he’s allergic to 40 out of 46 items tested for. So his skin is always broken out, even while doing the Allergy Immunotherapy injections, I’m averaging every 3rd day on giving him another bath & this shampoo is helping him so much! He will be completely broken out, red bumps & hives all over his body, I’ll give him a bath & within a few hours, or by the next morning (since I usually bathe right before bed) his skin has significantly improved, half the bumps will be gone, most of the hives are completely gone & the redness is nonexistent!The smell is really great as well, it’s a lighter scent, I don’t smell any chemicals or any of the normal medicated smell at all & it’s light enough you can smell it on your pup if you’re up close, but otherwise it’s not noticeable. The formula is decently thick, it’s not runny at all, but it suds up so great as well – another huge thing most medicated shampoos don’t do! You also only need a small amount, it actually advises how much to use on the bottle depending on how large your dog is, but it’s so easy to suds up, that you don’t need much at all. I have a 64lbs Pitbull & I only use 2 pumps on his whole back, 1 on each side & 1 pump on each leg & that’s about it. So the cost is a bit expensive, but it lasts forever with how little you need & with how well it works, its 100% worth it. The pump works great, it has the locking mechanism when you turn the pump to the side, so you don’t have to worry about it leaking, we transport it every weekend to our MIL’s house, and I just throw it in the bag, never leaked before, you don’t have to worry about it.I can’t recommend this shampoo enough or stress how well its been working for our 4 dogs!
Rose Schultz –
Excellent Medicated Shampoo!
This shampoo works great for my dogâs sensitive skin. It helps with itching, irritation, and keeps the coat soft and clean. Vet-recommended and totally worth it! ð¾ð
KenAl619 –
Effective relief for my service dogâs skinâsmells great too
Bought this for my black Labrador service dog after he started developing itchy, pimple-like bumps, mostly on his belly and underbelly, likely from a grass or food allergy. After the first wash, I noticed some relief, and by the third wash, his skin had mostly cleared, with scabs healing nicely. I followed the instructions carefully and continued regular use, even after the vet prescribed antibiotics as a precaution due to his exposure to different environments.The shampoo has a pleasant, subtle scent and doesnât irritate his skin. Someone complimented how great he smelled and how shiny his coat looked. I was asked for a pet, and the soft, fluffy compliment reminded me to write this review. Iâll keep using it as part of his care routine.
Cake Bliss –
Allergy relief one pump away
This dog shampoo has been a game changer! It lathers really good, gentle on your dog, doesnât leak because you can turn to lock it and most importantly works. I have a chocolate lab and a pit bull and theyâre BOTH allergic to EVERYTHING!our lab a BIG NASTY hot spot on his neck and we used this shampoo as well as his allergy medicine and it was PERFECT! Smells good, works well and I HIGHLY recommend using the foam that this brand has as well.
RaMona Schmitz –
Great Product for itching and certain skin conditions on my pup
This is the best for skin condition that my pup had last December, he itched 24/7 and I felt so bad for him. His fur started falling out and his skin was red and bleeding,even had scabs on the bottoms of his ears. So his groomer used this on him and he started getting better from that moment on. I would give him a bath every third day for two weeks and left the shampoo in for 10 minutes and rinsed really good, he just kept getting better and better. After two weeks he was just like new and skin was cleared up and no more itching. So I would definitely recommend this product for a skin condition like my dog had helped him so much and put my mind at ease.
Heather Graham –
Great shampoo!!
My frenchie has severe allergies. After a food change, and bathes once a week with this shampoo, he feels so much better. Iâve even been able to stop his Cytopoint injections. The shampoo is very mild to be a chlorhexidine shampoo. I thought it might dry him out, especially using it once a week, but it hasnât. It works very well, and smells nice too.
Andres Valencia –
les deja el pelaje suavecito y limpio
Marion –
Exactly as described. Beautiful scent and a little amount goes a long way. Love it.
SG Tho –
This shampoo will make your pet fur so soft and shiny . And the best part is reduce her dander by 75% ⦠she is more calm now .. less scratchy. Since we live in humid so I shower her every 4 – 5 days .
Lim Bee Lian –
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Jess –
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