Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 2-Month Supply
Original price was: $33.58.$32.58Current price is: $32.58.







Price: $33.58 - $32.58
(as of Oct 08, 2025 03:05:47 UTC – Details)
Advantage II Large Cat is a vet-recommended, leading brand in cat flea protection. Advantage II Large Cat flea treatment and prevention kills adult fleas, flea larvae and flea eggs to deliver total flea protection to your cat or kitten. Within 12 hours of application, Advantage II Large Cat topical treatment gets straight to work killing fleas through contact, so they don’t have to bite your cat to die. This treatment works hard for 30 days following application, effectively breaking the flea life cycle, controlling existing flea infestations and preventing further infestations all month long.
Fleas not only cause discomfort; they can also pose other health risks. Monthly use of Advantage II Large Cat is important to protect your cat against fleas that may cause transmission of tapeworms, Flea Allergy Dermatitis and flea bite anemia.
That’s why Advantage II Large Cat makes applying treatment simple. This convenient, spot-on application goes on the back of your cat’s neck at the base of the skull. You’ll simply place the tip of the tube on the skin and squeeze the tube to expel the entire contents directly on the skin. It goes on in seconds! It’s easier than a flea collar and there are no hard-to-swallow pills. You’ll also love that Advantage II Large Cat is fragrance-free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects.
Advantage II Large Cat flea protection is effective on both indoor and outdoor cats. Your cat should be at least 8 weeks old and weigh over 9 lbs. to use Advantage II Large Cat.
For the ultimate convenience in care, Advantage II Large Cat is available over the counter – no prescription needed. And, you can stock up with a subscription for regular doorstep deliveries so you never miss a monthly treatment.
Advantage II Large Cat is a trademark of Elanco or its affiliates.
Is Discontinued By Manufacturer : No
Product Dimensions : 1 x 4.38 x 4.75 inches; 0.64 ounces
Item model number : 86336677
Date First Available : September 1, 2014
Manufacturer : Elanco US Inc
ASIN : B00N7DEFH6
Best Sellers Rank: #56 in Pet Supplies (See Top 100 in Pet Supplies) #1 in Cat Flea Drops
Customer Reviews: 4.5 4.5 out of 5 stars 75,832 ratings var dpAcrHasRegisteredArcLinkClickAction; P.when(‘A’, ‘ready’).execute(function(A) { if (dpAcrHasRegisteredArcLinkClickAction !== true) { dpAcrHasRegisteredArcLinkClickAction = true; A.declarative( ‘acrLink-click-metrics’, ‘click’, { “allowLinkDefault”: true }, function (event) { if (window.ue) { ue.count(“acrLinkClickCount”, (ue.count(“acrLinkClickCount”) || 0) + 1); } } ); } }); P.when(‘A’, ‘cf’).execute(function(A) { A.declarative(‘acrStarsLink-click-metrics’, ‘click’, { “allowLinkDefault” : true }, function(event){ if(window.ue) { ue.count(“acrStarsLinkWithPopoverClickCount”, (ue.count(“acrStarsLinkWithPopoverClickCount”) || 0) + 1); } }); });
Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
Vet-recommended, easy-to-apply monthly topical treatment – no hard-to-swallow pills, no prescription needed
Delivers total flea protection – kills adult fleas, flea larvae and flea eggs through contact
Same-day effectiveness – kills fleas within 12 hours of application and keeps working for 30 days
Fragrance-free formula, waterproof after 24 hours of application
Customers say
Customers find the flea treatment effective, noting it works quickly and keeps fleas away with no sign of infestation. The product receives positive feedback for its quality, being better than Frontline, and customers appreciate its ease of application at the base of the cat’s head. While some customers report their pets are itch-free, others mention their cats continue to scratch. The effectiveness shows mixed results, with some customers reporting dead fleas after 12 hours while others note it only lasts about 2 weeks.
8 reviews for Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 2-Month Supply
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Original price was: $33.58.$32.58Current price is: $32.58.
tara speece –
Reliable Flea Protection That Works Quickly
Iâve been using Advantage II for my large cat (over 12 lbs), and itâs the only flea treatment I fully trust. Within just a day of applying it, I noticed a big differenceâscratching stopped, and I wasnât finding fleas on her bedding anymore. By the second day, the fleas were completely gone.Application is simple: just part the fur at the base of the neck and apply directly to the skin. My cat tolerates it well, and the formula dries quickly without leaving a greasy mess. I also appreciate that itâs waterproof after 24 hours, so I donât have to worry if she gets into a little rain or needs a bath.The 4-month supply is cost-effective compared to buying single doses, and I like knowing I can stay ahead of any infestations. This product really delivers on prevention as wellâno fleas have come back in between monthly doses.If you have a bigger cat and need something safe, effective, and vet-recommended, this is an excellent choice. It gives peace of mind and keeps both your cat and your home flea-free. Highly recommend!
V. Roberts –
Excellent. Worth the money.
I have four cats ⦠one very occasionally goes outside on a leash and one trip resulted in fleas that went unnoticed until all four had them.At first I tried Amazonâs version of flea treatment. Itâs crap. Donât buy it. Zero stars. Do not recommend. It only kills fleas, but not eggs or larvae, so itâs pointless.When I used this, after 24 hours I could no longer see any living fleas on any of my cats. Itâs now been a month and only the cat that brought the fleas in has had the occasional flea (maybe one a week). I just gave them all another dose today and am hoping I donât have to do it again.Note: while this does work, make sure you thoroughly wash or discard all pet bedding and wash your own bedding. Thoroughly clean carpets if you have them. I even threw away a cat tree that I just couldnât clean well enough.
HMJ –
Must have
It works great. My cat had fleas and the neighbors cat gave them to him so I had to treat them both. Worked like a charm. After about a week of treating my home and the cats the fleas were long gone. It last over a month from what I can see, it doesnât smell from what I can smell, and my 9 pound cat takes it well.
S. Police –
glad my vet recommended this – so far
just giving 4 stars for now because it’s only been a weekend. i want to see if this is long lasting and i’ll come back with update. but for my use of it, it was fairly easy, i put the liquid in the back of neck between shoulder blades and let it doe it’s work. so far my indy is very comfy. i used this in conjunction with capstar, and used a good premise spray for the house. so far the combo seems to be working. this was all recommended by my vet – so i’m glad i reached out because the other product i bought in petco did not work much longer than a day.
Lacy Jane –
No More Itchy BusinessâOur Streetwise Cat Is Now Pest-Free and Fancy
This monthly flea treatment deserves a standing ovation (or at least a slow blink of approval from our formerly feral feline). After adopting us post-cat fight and claiming our porch as his kingdom, he brought along a few unwanted guestsâtiny, jumpy, itchy ones. We needed something effective, fast, and drama-free.This stuff? Total win. Application was a breezeâno wrestling match, no betrayal stares. Just a quick squeeze between the shoulder blades and voilà : flea eviction notice served. Within days, he was lounging like a spa guest, not a flea motel.Now heâs neutered, healed, and living his best lifeâstill flea-free, still fabulous. If your cat has a flair for the dramatic or a past life as a street brawler, this treatment is the peace treaty youâve been waiting for.
sandra middendorf –
It works like the packaging says.
We have purchased this in the past and it eradicated the fleas with 2 hours. Didn’t make our cat sick. Price point is good too.
Anna Heil –
Best Cat flea product, period.
Never will I buy anything else but Advantage II, because once you find a good thing you should always stick with it. And I tried to save money and get me another brand. Never again, I’ve been using Advantage II for years and years. And will continue too for many more.
Haehl –
Maybe I just have super fleas
Kinda dont know, ever I have super flea or this isn’t entirely effective