FRONTLINE Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs. 3 Treatments
Original price was: $44.99.$34.98Current price is: $34.98.
Price: $44.99 - $34.98
(as of Oct 11, 2025 16:57:27 UTC – Details)
Keep your dog protected with the number 1 name in flea & tick protection (1), FRONTLINE. FRONTLINE Plus for Dogs is a fast-acting, long-lasting waterproof flea & tick topical that’s proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease. Break the flea life cycle — FRONTLINE Plus for Dogs is specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control. Trusted by pet owners for over 20 years (2) — FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply. Applied to a single point on your pet, the flea and tick control treatment covers your dog’s entire body and deposits in the sebaceous glands. These glands act as a reservoir, continuously replenishing the treatment onto your pet, working even if your dog gets wet. Just one dose of FRONTLINE Plus each month protects against fleas & ticks for a full 30 days. FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products. Appropriately treat all pets in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations. Subscribe and save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus. Be sure to visit our brand store and follow us to stay up to date on new FRONTLINE products, features, tips and more. References: (1) BI Marketing Excellence Survey performed by Kynetec, November 2023. (2) 20 years of trust in killing fleas and ticks demonstrated by various studies in the past 20 years including a 2002 Pet Owner Brand Awareness and Attitude Tracking Study performed by Bruno and Ridgway Research Associates and the 2023 BrandSpark© American Trust Study where FRONTLINE Brand Products were voted most trusted for brand for flea & tick prevention.
Is Discontinued By Manufacturer : No
Product Dimensions : 5.75 x 0.75 x 4.5 inches; 0.64 ounces
Manufacturer recommended age : 1 month and up
Item model number : 72219
Department : Insect Control
Date First Available : September 2, 2004
Manufacturer : Boehringer Ingelheim Animal Health
ASIN : B0002J1FOE
Best Sellers Rank: #172 in Pet Supplies (See Top 100 in Pet Supplies) #3 in Dog Flea Drops
Customer Reviews: 4.4 4.4 out of 5 stars 48,627 ratings var dpAcrHasRegisteredArcLinkClickAction; P.when(‘A’, ‘ready’).execute(function(A) { if (dpAcrHasRegisteredArcLinkClickAction !== true) { dpAcrHasRegisteredArcLinkClickAction = true; A.declarative( ‘acrLink-click-metrics’, ‘click’, { “allowLinkDefault”: true }, function (event) { if (window.ue) { ue.count(“acrLinkClickCount”, (ue.count(“acrLinkClickCount”) || 0) + 1); } } ); } }); P.when(‘A’, ‘cf’).execute(function(A) { A.declarative(‘acrStarsLink-click-metrics’, ‘click’, { “allowLinkDefault” : true }, function(event){ if(window.ue) { ue.count(“acrStarsLinkWithPopoverClickCount”, (ue.count(“acrStarsLinkWithPopoverClickCount”) || 0) + 1); } }); });
Keep your dog protected from fleas & ticks all month long with FRONTLINE Plus for Dogs a fast-acting, waterproof flea & tick topical that’s proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
Break the flea life cycle with FRONTLINE Plus, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea control
Trusted by pet owners for over 20 years, FRONTLINE Plus for Dogs can be used on puppies as young as eight weeks old, weighing 5 pounds or more, and is easy to apply with one monthly dose providing protection from fleas & ticks for a full 30 days
FRONTLINE Plus also comes in a formula designed for cats and kittens eight weeks of age and older, 1.5lbs. and over, so you can protect the dogs or cats in your house from fleas and ticks with FRONTLINE Brand Products
Treat all dogs or cats in your household monthly to effectively control fleas and ticks and prevent the establishment of new flea infestations
Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus
Subscribe & save today to make it easier to keep your dogs or cats protected year-round and make sure you never run out of FRONTLINE Plus
Customers say
Customers find this pest control product to be the gold standard for flea and tick prevention, protecting dogs year-round and being easy to apply along the back. The effectiveness and flea control receive mixed feedback – while some say it works great and keeps fleas away, others report it doesn’t work at all or doesn’t kill fleas. Customers disagree on the value for money, with some saying it’s great for the price while others consider it worthless. Skin reactions are mixed, with some reporting no adverse reactions while others experience intense itching, and the product’s duration varies, with some saying it lasts months while others report it only lasts two weeks.
12 reviews for FRONTLINE Plus Flea and Tick Treatment for Large Dogs Up to 45 to 88 lbs. 3 Treatments
Add a review
Related Products
Original price was: $44.99.$34.98Current price is: $34.98.
Louise –
Good Flea & Tick Control
Due to our dog’s previous kidney issues, I avoid chewable flea treatment that may have been involved.The Frontline month liquid treatment is easy to apply along his back and seems to provide good flea & tick control.
Amazon Customer –
Tried and true product for Lyme disease prevention
Tried and true product. As a general rule, I do not like having to put chemicals on my dogs. But we live in an area where the ticks are atrocious and some years are worse than others. So I struggle with putting chemicals on the dogs versus having them contract Lyme disease so I do use this product when I feel that I have to. I have never had a dog have a reaction to Frontline, and we have had dogs for 25 years. It works immediately. I wish they would come out with a product like this for people. I had a tick crawling down my neck the other day and it really freaked me out.Good price and fast shipping.
Sarah Bristol –
Happy
Doesnât work for me anymore but it is a good thing
Peter Suslock –
Your Safest Bet For A Product You Wish You Didn’t Need.
Allow me to caveat this review by saying out of 700 plus reviews this is the most difficult to write as I despise having to use pesticides on our dogs. That said, we live in Tick and Flea central, surrounded by deep woods and our bulldogs are in every sense of the word family and we do whatever we must to protect them. That said if you’re reading these reviews your dog or dogs are your heart too and using these products is a difficult choice to make, but it’s one we have to make.On that note, it’s my hope the following information has some value for you.Frontline was first put into clinical trials in 1985 shortly after the discovery of it’s active ingredient Fipronil. To it’s credit Frontline has maintained the safest albeit not the most effective treatment for fleas and ticks. However, the more effective products pose a significantly greater risk to your dog.It’s a slippery slope, but in evaluating what’s best for your dog by providing the highest level protection with the lowest risk Frontline and FrontLine Plus are in my opinion your best bet.Most tick and flea products contain Permethrin which may also be listed as Lyclear or Nix as the active ingredient. Permethrin is a lethal neurotoxin that flows through the dogs circulatory system and flushes into every major organ – including the brain where it can do dire damage. Thousands of dogs die every year from Permethrin. Although the FDA has mandated a minimal use not to exceed 750PPM companies continue to ignore the guidline because it’s cheap and effective, and sadly it’s our dogs that pay the price.What makes Permethrin so dangerous is that it can’t distinguish between insects and mammals which of course includes human beings. It’s been known to be lethal to cats since the 1970’s. In fact it’s so deadly to cats that even a slight transfer from dog to cat can result in seizures, brain damage and death. Permethrin is volatile as well – meaning it’s airborne properties pose a threat to all who breath it in – humans included.Frontline on the other hand uses Fipronil. Fipronil is an insecticide.Like any chemical of this nature it can be lethal at too high of a dose. However studies including those from the Department of Environmental Conservation have determined time and time again that as long as the amount of Fipronil is at the correct dose for the weight and size of your dog toxicity is far easier to avoid and the product much safer for your dog. Unlike Premethrin, Fipronil is absorbed into the hair follicles and oil glands only. It is not absorbed into the dogs system nor is it volatile so you and your beloved pets and children can breath easy. The second active ingredient in FrontLine Plus is Methoprene which is a long existing and time proven IGR (insect growth regulator) it’s distributed exactly like Fipronil but only acts on flea and tick eggs and Larvae – this is important because it kills these vermin at the start of a new life cycle. What is more, the diseases that ticks carry now are infinitely more serious than the dreaded Lime disease – which for decades was the only concern.Competitors to Frontline (and some Vets selling other products) claim that fleas and ticks have become resistant to Frontline – However these pests have become resistant to some degree to all pesticides and no independent research exists to confirm this claim. I can assure you I’ve researched this in the greatest depth.The bottom line is this – all of these products pose a risk.The wise choice is to minimize that risk in your effort to protect your best friend from the diseases these vermin carry. Again, these diseases can be infinitely more lethal than the ingredients of the protection. To that end your safest and most effective choice is Frontline or Frontline Plus.In the event your pet has a bad reaction to Frontline products these are the symptoms you would see:* Restlessness* Itching* Vomiting* Difficulty Breathing* LethargyShould these symptoms occur, of course take your pet to your Veterinarian or emergency clinic immediately. It should be a comfort to know that unlike the toxic ingredients in most other flea and tick control products severe reactions to both Fipronil and Methoprene are rare.
Juan Luis –
the most
Excellent product! Keeps my dog completely free of fleas and ticks, easy to apply and very effective.
MW –
Reliable Protection Year After Year
Iâve been using FRONTLINE Plus on my large dog (around 80 lbs) for years, and it has never let me down. Living in an area where fleas and ticks are common, I needed something I could trust, and this product has consistently kept my dog protected.Itâs very easy to apply once a month, and my dog has never had any irritation or side effects. I also appreciate that it works quickly, I usually notice a difference within a day or two. The 3-pack is convenient because it covers a full season without having to reorder right away.After years of use, I can confidently say this is a dependable flea and tick treatment that does exactly what it promises.
Sheryl –
Didn’t prevent fleas but Seresto collar did
The Frontline Plus flea and tick control for 45 to 88 pound dogs was worse than a disappointment. My dog is 50 pounds–well within the dosage range and become infested with fleas during the second month/dosage of usage. I’m not sure if the preventative actually worked the first month or if I just didn’t notice the fleas until the fleas had multiplied enough for me to easily see them. I also don’t know if I received the same quailty Frontline product through Amazon as a store/vet purchase. I have no reason to think that this was an imitation product other than some suspicions by other reviewers. Regardless, I had to use a flea dip and flea bomb my house. Once an infestation occurs, getting rid of the fleas is quite an aggravation. I’m trying Advantage II from PetSmart now to see if that will work. Hopefully, something will.June 24 2013, Advantage II didn’t work either. I’ve had acceptable success from Certifect which I buy from my vet. I’ve used Certifect for over a year now. These flea and tick drops are made by Frontline but are only sold by prescription or thru a vetinarian. It works great for ticks. I’ve not had any problems with ticks from the first dosage. For a few days, though, after the dosage, he is a bit lethargic. However, my dog will still pick up fleas. The drops do kill the fleas but don’t repel them quickly enough. Many people are having trouble with fleas because of the sucession of mild winters. The flea population isn’t culled enough. During the summer months, the fleas just seem to overwhelm the medication and flea dips or additional organic sprays are necessary. I’ve been told that a new flea and tick pill may now be available. I know the flea pill works but I hadn’t used it because I needed something for ticks. If this rumor is true, I’ll definately give the pill a try.December 30, 2014. I finally found something that actually works for controlling fleas and ticks for my now 70 pound Labrador/mix. (He was a stray that my family adopted–short hair.) My vet introduced me to a new product (at the time) made by Bayer. It’s a flea collar called Seresto that is sold on Amazon. I couldn’t believe that a flea collar would really work. But, after having to hire Orkin to get the fleas out of my home, I was willing to try it. It’s the best product that I have used for fleas and ticks. It’s easy to use. I just put the collar on my dog. In few days all fleas were gone. The only ticks I ever find on my dog are the ones that he picks up during a walk or bush adventure. They are easily brushed off (when I notice them) and never attach. The collar lasts as long as advertised–8 months or in our case 5 months since he likes to swim. Unlike the drops, he is never lethargic afterwards. I have used several of these Seresto collars now and can’t recommend them enough. They are sold on Amazon, by veterinarians, and I’ve seen them at Pet Smart as well.
John c magruder –
A great product for the price
Great and effective product
Douglas fernandes –
It was very helpful I managed to get control of the continue scratching on her back
Ava Alipanah –
Very excellent and high quality
Sen Sen –
It works
Ashley P –
My dog got extremely ill for 3 days afterwards . Seller doesnât allow returns!