Douxo S3 Calm Shampoo, Contains 0.75% Ophytrium, Soothing, For Itchy, Irritated or Allergic Skin, For Dogs and Cats, 6.7 fl. oz. (200mL)
$23.99
Price: $23.99
(as of Oct 24, 2025 13:54:19 UTC – Details)
Formulated to help soothe allergic, itchy or irritated skin of dogs or cats. Moisturizes and detangles the fur to leave the coat soft and shiny. DOUXO is the 1 non-prescription topical brand used and recommended by U.S. veterinarians for dogs cats with allergic dermatitis.
Package Dimensions : 6.02 x 2.64 x 1.97 inches; 8.78 ounces
Item model number : D98110P
Date First Available : May 5, 2021
Manufacturer : Douxo S3
ASIN : B09478KGJZ
Best Sellers Rank: #1,349 in Pet Supplies (See Top 100 in Pet Supplies) #12 in Dog Shampoos
Customer Reviews: 4.6 4.6 out of 5 stars 3,175 ratings var dpAcrHasRegisteredArcLinkClickAction; P.when(‘A’, ‘ready’).execute(function(A) { if (dpAcrHasRegisteredArcLinkClickAction !== true) { dpAcrHasRegisteredArcLinkClickAction = true; A.declarative( ‘acrLink-click-metrics’, ‘click’, { “allowLinkDefault”: true }, function (event) { if (window.ue) { ue.count(“acrLinkClickCount”, (ue.count(“acrLinkClickCount”) || 0) + 1); } } ); } }); P.when(‘A’, ‘cf’).execute(function(A) { A.declarative(‘acrStarsLink-click-metrics’, ‘click’, { “allowLinkDefault” : true }, function(event){ if(window.ue) { ue.count(“acrStarsLinkWithPopoverClickCount”, (ue.count(“acrStarsLinkWithPopoverClickCount”) || 0) + 1); } }); });
DOUXO S3 CALM Shampoo helps provide your dog or cat with soothing relief from the discomfort of itching and inflamed skin due to allergies
#1 non-prescription topical brand used and recommended by US veterinarians for dogs and cats with allergic dermatitis (itchy skin due to allergies)
Detangles fur and leaves the hair and coat soft and shiny, and helps repair skin ecosystem
Helps interrupt the vicious cycle of itching, with results seen in as little as 7 days, and the best results seen after 21 days
Safe for long-term use, for best results use with DOUXO S3 CALM Mousse
Customers say
Customers report that the shampoo effectively reduces itching, particularly for dogs with skin issues, and helps moisturize and brighten their coats. The product receives positive feedback for its quality, with one customer noting it works well for flea bites, and customers appreciate its amazing scent without perfumes. While many customers find it worth the cost, others consider it pricey.
11 reviews for Douxo S3 Calm Shampoo, Contains 0.75% Ophytrium, Soothing, For Itchy, Irritated or Allergic Skin, For Dogs and Cats, 6.7 fl. oz. (200mL)
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Mama Celeste –
Helped my doggy a lot!
This is great stuff! Calming doggy shampoo for desperately itchy or allergic dogs, and it’s the best dog shampoo product I have ever tried! It is not fragranced but smells clean, lathers so very well, rinses well, conditions fur well without needing any additional conditioner, and best of all, it works! My girl is not itchy anymore! You won’t regret trying it, and although the price seems high, it lathers so well that you only need a palm-sized dollop to wash one whole small dog.
Austin –
A Lifesaver for My Dogâs Skin â Worth Every Penny
Iâve tried a lot of products to manage my dogâs skin issues, but Douxo S3 Calm is the only shampoo thatâs consistently helped. My golden retriever, Luna, has a dust mite allergy and a history of sensitive skin and occasional staph infections, especially when staying in dusty or older environments. This shampoo has become part of our routine, and itâs made a real difference.Itâs gentle, fragrance-free, and doesnât dry her out â even with more frequent use. Her skin looks calmer, less red, and she scratches way less after a bath. Iâve noticed fewer flare-ups since switching to this and sticking to a consistent bathing schedule.If your dog has allergy-prone or reactive skin like mine, this is the one to try. Itâs pricey, but it actually works â and thatâs what matters.
Stphne –
Great for dogs with sensitive skin
It works wonderfully. I recommend it 100%. I would buy it again. It doesnât have a scent.
Demi –
Not sure yet.
I purchased this one after the orange bottle seemed too harsh for my dogâs skin. I have only used it once, and it seemed to work well, and he didnât have the redness all over his body, like with the other one, but a few days later his skin was peeling again. This didnât seem to bother him as much as the other one, as the peeling didnât turn to scabs. It smells nice, but again, Iâll think Iâll only apply it to his feet. The mousse works well also, and again is much more gentle than the orange bottle.
Grace Moss –
Highly recommended brand by vets, great for itchy sensitive skin.
Great for dogs with sensitive skin like my dog. Helped to alleviate the itch, plus the smell isn’t overpowering or “perfumey” goes on smooth. The shampoo quality is just right, not too thick, not too thin. Duoxo brand was recommended by my vet.
Taylor –
Allergy shampoo recommended by vet
My vet told me to use this for two of my dogs with allergies and sent me home with it. When I saw that it could be bought on Amazon I was very happy bc obviously itâs cheaper. It helps them along with their other care.
Kenneth_Lemoine –
Fantastic product to reduce/eliminate the itching
Your dog will love after the bath. It is really effective when it comes to reduce/eliminate the itching on my dog. Fantastic product
Wineisgood –
Great products, however Douxo has horrible Customer Service
Great Product.Horrible Customer Service from Douxo.Shampoo worked great with my dogs skin allergies. Pump was broken upon arrival from product packing, not damaged in shipping. Reached out to Douxo Customer Service directly and they would not replace pump.Because of the size/shape of the bottle I was unable to find a replacement pump, causing the product to be over used and only last a few months.As a long time Douxo customer, I am extremely disappointed and working with my vet office for an alternative brands for my dogs in the future.
Jess –
Works well
Esther Ang –
At first few use, it doesnât seem to do much. But after repeated use for 3 months, can sense the dog skin slightly improving. It is not as effective as Malaseb (another brand), but it is less drying than that.
SG Tho –
Help with dog itching